In recent years, PDRN (Polydeoxyribonucleotide) has emerged as a revolutionary ingredient in medical aesthetics, especially for anti-aging, skin repair, and tissue regeneration. Often referred to as “salmon DNA”, PDRN is not just a skincare trend—it's a powerful therapeutic agent used by doctors and aesthetic professionals around the world.
In this blog, we'll explain what PDRN is, how it works, and—most importantly—how it is used in modern aesthetic treatments to deliver real, lasting results.
PDRN is a low molecular weight DNA compound extracted from salmon sperm cells, known for their high compatibility with human DNA. It has regenerative, anti-inflammatory, and pro-healing properties, making it ideal for aesthetic and dermatological use.
Unlike superficial skincare ingredients, PDRN injection works at the cellular level, where it:
Stimulates fibroblast activity
Enhances collagen and elastin production
Accelerates wound healing
Reduces inflammation and oxidative stress
PDRN can be incorporated into several professional aesthetic treatment protocols, depending on the patient's skin needs. Below are the most common medical uses and application methods in clinics and medical spas.
This is the most effective and widely used method. Using a fine needle (30G-34G), small amounts of PDRN are injected directly into the dermis, targeting specific problem areas. This technique ensures precise delivery to targeted areas, promoting rapid tissue regeneration.
Depth: Precise dermal placement (1.0-2.0mm)
Ideal for:
Acne scars
Pigmentation
Skin texture and dullness
Large surface areas (full face)
Sensitive skin (no direct injection)
Advantage: No injections, but delivers similar rejuvenation, suitable for all skin types (including sensitive skin)
Procedure Steps:
Skin Preparation – Cleansing and numbing cream (optional).
Microneedling – A pen or roller (0.5-2.0mm depth) creates microchannels.
PDRN Application – Serum is massaged into the skin for deep penetration.
Recovery – Redness subsides in 1-3 days; sunscreen is mandatory.
Microneedling creates micro-channels in the skin to enhance absorption of PDRN serums. After the needling step, the PDRN solution is applied to the skin, allowing it to penetrate deep into the dermis. This enhances absorption and stimulates collagen remodeling.
Depth: Adjustable (0.5-2.0mm)
Ideal for:
Acne scars
Pigmentation
Skin texture and dullness
Large surface areas (full face)
Sensitive skin (no direct injection)
Advantage: No injections, but delivers similar rejuvenation, suitable for all skin types (including sensitive skin)
Procedure Steps:
Skin Preparation – Cleansing and numbing cream (optional).
Microneedling – A pen or roller (0.5-2.0mm depth) creates microchannels.
PDRN Application – Serum is massaged into the skin for deep penetration.
Recovery – Redness subsides in 1-3 days; sunscreen is mandatory.
In mesotherapy, multiple micro-injections of PDRN are applied to the skin using either a manual needle or a meso gun. The injections are spaced evenly across the face, ensuring even distribution and maximum absorption.
Depth: Superficial (1.0-1.5mm)
Ideal for:
Full-face rejuvenation
Even distribution needs
Hair thinning or scalp treatment
Advantage:
Superficial injections into the mid-to-upper dermis
Fast coverage of large areas
Procedure Steps:
Marking the Treatment Area – A grid pattern ensures uniform injection points.
Shallow Injections – PDRN is delivered at 1-2mm depth (minimal pain).
Post-Care – Mild swelling may occur; avoid sun exposure for 48 hours.
Method | Precision | Coverage | Downtime | Ideal Case |
Direct Injection | ★★★★★ | ★★☆☆☆ | 1-2 days | Focused anti-aging |
Microneedling | ★★★☆☆ | ★★★★☆ | 3-5 days | Texture correction |
Mesotherapy | ★★☆☆☆ | ★★★★★ | 1 day | Global rejuvenation |
PDRN can be used alone or in combination with other treatments, such as:
Hyaluronic Acid: for hydration and volume
Botulinum Toxin: to smooth dynamic wrinkles
Laser Treatments: to reduce recovery time and improve healing
Combining PDRN with other procedures enhances its effectiveness and shortens downtime.
Yes. PDRN has been clinically tested and is well-tolerated by most patients. Side effects are minimal and may mild redness or swelling at the injection site.
Because PDRN is extracted from salmon DNA, it does not trigger immune reactions in humans. However, professional application by trained providers is essential for safety and effectiveness.
PDRN is transforming the way we approach skin rejuvenation. Whether used in injections, mesotherapy, or microneedling, it offers biological regeneration rather than surface-level fixes. By working at the cellular level, it helps rebuild youthful, healthy skin from within.
For personalized treatment plans, consult a licensed dermatologist or aesthetic practitioner.
If you're a professional aesthetic provider, distributor, or clinic, incorporating PDRN treatments can elevate your service offerings and deliver results your clients will love.
Looking for high-quality PDRN ampoules for injection or microneedling?
We are a certified manufacturer and supplier of advanced PDRN-based solutions for medical aesthetic use.Contact us today for wholesale pricing and clinical product support.
