Author: Site Editor Publish Time: 05-22-2025 Origin: Site
In recent years, PDRN (Polydeoxyribonucleotide) has become a familiar ingredient in medical aesthetics, especially in skin quality–focused treatments. Often associated with “salmon DNA,” PDRN is widely used by aesthetic professionals not for dramatic contour changes, but for improving texture, elasticity, and overall skin condition.
If you’re new to PDRN or want a broader understanding of how it fits into aesthetic care, you can start with our overview of PDRN-based aesthetic treatments.
In this article, we’ll focus on something more practical: how PDRN is actually used in aesthetic treatments, and why application method matters.
PDRN itself stays the same—but how it’s applied can make a big difference in results, downtime, and suitable skin types.
In aesthetic practice, PDRN aesthetic treatments is not a one-size-fits-all solution. Clinics choose different delivery methods based on skin condition, treatment goals, and patient comfort. The most common approaches include injection-based PDRN treatments, microneedling-assisted applications, and mesotherapy-style techniques.
Each method serves a slightly different purpose.
Direct injection is one of the most widely used ways to apply PDRN in professional settings. Small amounts of PDRN solution are placed into specific skin layers using fine needles (30G-34G), allowing practitioners to target areas that need deeper support.
Depth: Precise dermal placement (1.0-2.0mm)
Ideal for:
uneven skin texture
early signs of aging
areas with post-acne marks
under-eye or facial skin quality concerns
Advantage: Delivered precisely, injections are usually chosen when clinics want consistent and controlled skin response, rather than surface-level improvement.
Procedure Steps:
Skin Preparation – Cleansing and numbing cream (optional).
Injection– A pen or roller (0.5-2.0mm depth) creates microchannels.
PDRN Application – Serum is massaged into the skin for deep penetration.
Recovery – Redness subsides in 1-3 days; sunscreen is mandatory.
For a full breakdown of indications, benefits, and expectations, you can explore our injection-based PDRN treatments guide.
Another common method is microneedling-assisted PDRN application. Instead of injecting the product, microneedling creates micro-channels in the skin, allowing PDRN solutions to penetrate more effectively.
Depth: Adjustable (0.5-1.0mm)
Ideal for:
Acne scars
Pigmentation
Skin texture and dullness
Large surface areas (full face)
Sensitive skin (no direct injection)
Advantage: No injections, but delivers similar rejuvenation, suitable for all skin types (including sensitive skin)
Procedure Steps:
Skin Preparation – Cleansing and numbing cream (optional).
Microneedling – A pen or roller (0.5-2.0mm depth) creates microchannels.
PDRN Application – Serum is massaged into the skin for deep penetration.
Recovery – Redness subsides in 1-3 days; sunscreen is mandatory.
Microneedling-based PDRN applications are popular for patients who prefer minimal injections while still aiming for visible skin quality improvement over time.
In mesotherapy, multiple micro-injections of PDRN are applied to the skin using either a manual needle or a meso gun. The injections are spaced evenly across the face, ensuring even distribution and maximum absorption.
Depth: Superficial (1.0-1.5mm)
Ideal for:
Full-face skin quality programs
Even distribution needs
Maintenance-focused treatments
Advantage:
Superficial injections into the mid-to-upper dermis
Fast coverage of large areas
Procedure Steps:
Marking the Treatment Area – A grid pattern ensures uniform injection points.
Shallow Injections – PDRN is delivered at 1-2mm depth (minimal pain).
Post-Care – Mild swelling may occur; avoid sun exposure for 48 hours.
Method | Precision | Coverage | Downtime | Ideal Case |
Direct Injection | ★★★★★ | ★★☆☆☆ | 1-2 days | Focused anti-aging |
Microneedling | ★★★☆☆ | ★★★★☆ | 3-5 days | Texture correction |
Mesotherapy | ★★☆☆☆ | ★★★★★ | 1 day | Global rejuvenation |
In real-world aesthetic practice, the choice of method often comes down to skin condition and treatment goals:
Uneven texture or post-acne skin: microneedling or targeted injections
Early aging and elasticity concerns: direct injection or mesotherapy
Sensitive or stressed skin: gentler delivery methods with gradual buildup
Rather than asking which method is “best,” professionals usually ask which approach fits the skin’s current condition.
Yes—PDRN is frequently used alongside other aesthetic procedures. It’s often included in programs with hydration-focused treatments, wrinkle-relaxing procedures, or energy-based devices.
In many cases, PDRN is valued for its ability to support skin comfort and recovery, making it a useful addition rather than a standalone solution.
Professional PDRN formulations used for injections need to meet higher standards than topical or cosmetic-grade products. Clinics and distributors typically look for solutions that offer:
high-purity PDRN suitable for injectable use
stable formulation with predictable skin response
smooth injection performance and consistency between batches
This is where Mesocel® PDRN is commonly selected in professional settings.
Mesocel® PDRN is a salmon-derived PDRN formulation developed specifically for aesthetic injection protocols. Produced by Dermax, it is designed to support skin-quality-focused treatments where reliability and consistency matter. It is widely used in facial skin quality treatments, under-eye protocols, and recovery-oriented aesthetic programs where subtle, repeatable improvement is preferred over aggressive intervention.
PDRN is not used in aesthetics for instant transformation. Its strength lies in flexibility—multiple application methods, adaptable treatment planning, and gradual skin quality improvement.
Whether delivered through injections, microneedling, or mesotherapy, PDRN gives professionals options. By choosing the right method and formulation, clinics can tailor treatments that support smoother texture, better elasticity, and healthier-looking skin over time.
