Author: Site Editor Publish Time: 12-17-2025 Origin: Site
PDRN microneedling is a skin rejuvenation treatment that combines traditional microneedling techniques with topical or transdermal application of PDRN (Polydeoxyribonucleotide). Instead of injecting PDRN into the skin, microneedling creates controlled micro-channels that allow PDRN to be absorbed more effectively into the skin layers.
This approach is widely used in aesthetic practice for improving skin texture, hydration, and overall skin quality, especially for patients who prefer a minimally invasive treatment with little downtime.
Microneedling works by creating tiny, controlled micro-injuries on the skin surface using fine needles. These micro-channels stimulate the skin’s natural repair response and temporarily increase skin permeability, allowing active ingredients to penetrate more effectively.
When PDRN is applied during or immediately after microneedling, it can reach deeper skin layers through these micro-channels. At the cellular level, PDRN supports tissue repair by activating recovery pathways involved in wound healing and regeneration. Experimental and clinical studies, including research published in the International Journal of Molecular Sciences, have shown that PDRN promotes tissue regeneration through activation of the adenosine A2A receptor, a pathway known to support cell repair and anti-inflammatory responses.
Rather than altering facial structure or volume, microneedling with PDRN focuses on improving how the skin repairs itself, recovers after controlled injury, and maintains overall skin quality over time.
Microneedling alone stimulates collagen production through controlled injury. PDRN, on the other hand, supports cellular recovery and regeneration.
When combined:
Microneedling improves delivery
PDRN supports repair and regeneration
The skin recovery process becomes more efficient
This is why PDRN microneedling is often selected for patients dealing with dull skin, uneven texture, or early signs of aging, rather than those seeking dramatic contour changes.
Commonly reported benefits of PDRN microneedling include:
Improved skin texture and smoothness
Enhanced skin hydration and elasticity
Faster skin recovery after microneedling
More even-looking skin tone
A healthier, refreshed skin appearance
These improvements tend to develop gradually, which is why results usually look natural rather than obvious or artificial.
From a biological perspective, this effect is closely related to how PDRN supports skin repair. When combined with microneedling—a controlled form of skin injury—PDRN helps activate cellular recovery pathways involved in tissue regeneration. Research in dermatology and regenerative medicine suggests that PDRN can promote wound healing and tissue repair by stimulating fibroblast activity and modulating inflammatory responses. This mechanism helps explain why PDRN is frequently used alongside microneedling to support post-procedure recovery and overall skin quality.
A typical PDRN microneedling session includes:
Skin cleansing and preparation
Microneedling performed at controlled depth
Application of PDRN ampoule or solution
Post-treatment soothing and protection
The entire procedure usually takes less than 45 minutes, depending on the treatment area and protocol.
Downtime is generally minimal. Mild redness or sensitivity may occur and usually resolves within a short period.
One of the most common questions is whether PDRN can be used after microneedling.
In professional practice, PDRN is often applied immediately after microneedling while the micro-channels are still open. This timing allows better absorption and supports skin recovery.
When used correctly by trained professionals, PDRN microneedling is generally well tolerated. As with any aesthetic procedure, proper technique and patient assessment are essential. For a more detailed discussion on PDRN safety and clinical considerations, you may refer to our dedicated guide.
Before-and-after results of PDRN microneedling typically reflect gradual improvements in skin condition, rather than dramatic structural changes.
In real clinical cases, visible changes may be observed within the early recovery phase. In this example, approximately 12 days after treatment, the patient showed noticeable improvement in overall skin condition compared with baseline.
Observed changes included:
Smoother skin texture and improved skin clarity
Reduced acne activity and fewer active breakouts
Decreased inflammation, with less diffuse redness
Reduced appearance of redness and visible capillaries
Brighter-looking skin with a more even skin tone
These changes are consistent with the skin’s natural repair and recovery process following microneedling combined with supportive treatments. Results typically continue to develop over time, and individual outcomes may vary depending on skin condition, treatment protocol, and post-treatment care.
Before-and-after images should be interpreted as examples of potential improvement, not guaranteed results.
The longevity of PDRN microneedling results depends on treatment frequency and individual skin condition.
In clinical practice:
Initial protocols often involve 4-5 sessions, spaced 4 weeks apart
Skin quality improvements typically become more stable after the initial treatment course
Once the skin has responded, results are commonly maintained with periodic follow-up sessions every 3–6 months, depending on aging factors and lifestyle.
Rather than fading suddenly, improvements tend to decline gradually if maintenance treatments are discontinued.
Clinical feedback on PDRN microneedling commonly focuses on skin recovery and overall skin quality, rather than dramatic visual transformation.
Practitioners often note:
Improved post-procedure recovery
Better skin tolerance following microneedling
Gradual enhancement of texture and hydration
The cost of PDRN microneedling varies based on several practical factors:
Treatment area
Number of sessions required
Type and concentration of PDRN formulation
Clinical setting and practitioner expertise
Because protocols are often customized, pricing is usually determined as part of a treatment plan rather than a single session.
Both treatments use PDRN, but the delivery method is different.
PDRN Skin Booster treatments deliver PDRN directly into the dermal layers
PDRN Microneedling enhances transdermal absorption without injections
Microneedling is often chosen by patients who prefer less invasive options or want to combine treatment with overall skin resurfacing.
In professional aesthetic practice, PDRN microneedling protocols may involve formulations specifically designed for topical or transdermal use.
Examples include:
Mesocel® PDRN for Microneedling
Mesocel PDRN Mesotherapy With Microneedling
These products differ in concentration and formulation, and selection depends on treatment goals and practitioner preference.
PDRN microneedling may be suitable for individuals who:
Want to improve skin texture and quality
Prefer minimally invasive treatments
Are not seeking volume or structural changes
Are looking for gradual, natural-looking improvement
It is often used as part of a long-term skin maintenance strategy.
PDRN is used across several aesthetic treatment approaches, including:
Salmon-derived PDRN applications
Injectable PDRN skin booster treatments
Other PDRN-based aesthetic treatments
PDRN microneedling combines controlled skin stimulation with regenerative support. Rather than delivering instant or dramatic changes, it focuses on improving how the skin repairs itself and functions over time.
For patients and practitioners seeking natural skin rejuvenation with minimal downtime, PDRN microneedling has become a widely adopted option in modern aesthetic practice.
References
Galeano M, et al.
Polydeoxyribonucleotide improves wound healing by stimulating angiogenesis and fibroblast activity via adenosine A2A receptor activation.
International Journal of Molecular Sciences, 2018.
Available on PubMed Central.
Kim JH, et al.
The effect of polydeoxyribonucleotide on skin regeneration and wound repair in dermatologic applications.
Clinical, Cosmetic and Investigational Dermatology, 2016.
Available on PubMed.
