Botulax Storage Guide : How Long Does Botulax Last Once Mixed?

If you're a medical professional or clinic owner using botulinum toxin in your practice, you've likely worked with—or at least heard of—Botulax. Among the many brands on the market like Meditoxin, Nabota, Riztox (Hutox), and others, Botulax has earned its spot as South Korea's most trusted botulinum toxin, holding a nearly 40% market share and topping domestic sales for four years in a row.

Why is that? Simple. Botulax offers high purity, reliable results at low doses, and a solid safety record with very few adverse incidents. But even the best product loses its punch if it's not stored and handled correctly.

So let's answer the big question—and a few important ones around it:

How Long Does Botulax Last Once Mixed?

Once you've reconstituted Botulax with sterile 0.9% preservative-free saline, the clock starts ticking. Botulax should ideally be used within 24 hours after mixing. That's the standard rule in clinical settings.

However, if stored properly in a refrigerator at 2°C to 8°C (36°F to 46°F), it may remain clinically effective for up to 72 hours (3 days). Beyond that point, the risk increases that the active neurotoxin will lose its potency—leading to weaker or even ineffective results.

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Does Botulax Need to Be Refrigerated Before and After Mixing?

Yes, refrigeration is essential—before and after reconstitution.

Before mixing: Keep the vial in the fridge (2°C to 8°C). This ensures the toxin's stability and prevents early degradation.

After mixing: If not used immediately, the solution should be refrigerated again and used within 24–72 hours max. Most professionals prefer to use it on the same day to guarantee full effectiveness.

If you're managing a high-volume clinic, pre-scheduling appointments to align with reconstitution time is a smart move. It reduces waste and ensures patients always receive the most potent product.

How Do You Reconstitute Botulax?

Use sterile, preservative-free 0.9% sodium chloride (saline)

The common dilution ratio is:

100 Units Botulax + 2.5 mL saline = 4 Units per 0.1 mL

   Gently swirl—don't shake—the vial to dissolve the powder

⚠️ Professional use only: Always reconstitute and inject Botulax under sterile conditions and with proper anatomical knowledge. It's not something to DIY.

For reconstitution guidelines, check: How Much Saline Should Be Mixed With Botulax?

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How long is Botulax shelf stable?

Unopened Botulax vials, when stored under refrigeration (2°C–8°C), have a shelf life of up to 36 months from the manufacturing date.

However, once the vial is opened and mixed, shelf stability drops dramatically—so planning ahead is key.

Who Should Not Use Botulinum Toxin Injections?

While Botulax is incredibly safe when used by trained professionals, it's not for everyone. Here are some contraindications to keep in mind:

•    Pregnant or breastfeeding women

• Patients with neuromuscular disorders (e.g., myasthenia gravis, multiple sclerosis)
  

• Those with ptosis (drooping eyelids)
  

• Individuals with severe internal diseases (heart, liver, kidney issues)
  

• People with known allergies to botulinum toxin or excipients
  

Always review patient history thoroughly before proceeding with treatment.

Final Thoughts: It's Not Just About What You Use—It's How You Use It

Botulax has rightfully earned its reputation as South Korea's #1 botulinum toxin, offering high purity, reliable effects, and patient satisfaction at a competitive price. But even the best toxin can underperform if not stored and handled correctly.

So here's the bottom line:

✅ Reconstitute Botulax with preservative-free saline.

✅ Use it within 24 hours—ideally on the same day.

✅ Refrigerate it at all times, never freeze.

✅ Don't push its limits just to save a few dollars—your results depend on it.

✉ Want to become an Botulax distributor or clinic partner? Reach out today and join hundreds of professionals worldwide choosing smarter aesthetic solutions.

Whether you're using Botulax or other botulinum toxin products, consistent technique and safe storage practices are what truly deliver world-class results.