Mesolipo vs Mesotherapy: What’s the Difference?

In aesthetic medicine, mesotherapy is a broad concept. It's been used for decades to deliver active ingredients directly into the skin. But not all mesotherapy is the same. Mesolipo is one special type—focused entirely on fat reduction.

Many people confuse the two. Let's break it down simply.

What Is Mesotherapy?

Mesotherapy started in the 1950s in Mesotherapy started in the 1950s in France. The idea is simple: deliver a mix of nutrients, medicines, plant extracts, or other active ingredients into the middle layer of the skin.. The idea is simple: deliver a mix of nutrients, medicines, or other active ingredients into the middle layer of the skin.

It can be used for many purposes:

Skin rejuvenation

Hydration and glow

Pigmentation improvement

Hair loss treatment

How it works:

Mesotherapy works in a simple. Instead of relying on creams or supplements that have to travel through the whole body, the treatment places active ingredients right where they're needed. The tiny injections not only deliver nutrients directly into the skin, but also act like gentle “micro-wake-up calls,” encouraging your skin to produce more collagen and elastin. And because the formula can be tailored for each person, it can target exactly what's needed—whether that's hydration, brightness, or smoother texture.

Common ingredients include vitamins (C, A, E), minerals, amino acids, hyaluronic acid, peptides, and plant extracts. The mix depends on the patient's needs.

What Is Mesolipo?

Mesolipo, also called lipolytic mesotherapy, is all about breaking down fat cell, stubborn fat deposits. It's not for overall weight loss. Instead, it works on areas like the double chin, belly pooch, or love handles.

How it works:

The key player in most Mesolipo fat reduction formulas is deoxycholic acid (DA) or another proven fat-dissolving ingredient. DA works by breaking down the membrane of fat cells, causing them to release their contents. Once this happens, the body's natural processes gradually clear the excess fat away. Some formulations also add phosphatidylcholine (PC), L-carnitine, or caffeine to help speed up fat metabolism and improve results.

Typical treatment areas:

Under the chin

Abdomen (small pockets)

Thighs (inner or outer)

Bra bulge

Love handles

Learn more about Mesolipo injection before and after results.

Mesotherapy vs Mesolipo – Side by Side

Feature	Mesotherapy (Traditional)	Mesolipo (Fat-Dissolving)
Main goal	Skin health & rejuvenation	Localized fat reduction
Core ingredients	Vitamins, minerals, amino acids, HA, peptides	Deoxycholic acid, sometimes with PC, L-carnitine
Mechanism	Nourish & repair cells	Destroy fat cells (lipolysis)
Results	Better skin tone, texture, hydration	Slimmer, more contoured areas
Risks	Mild swelling, bruising	Higher swelling, possible nerve injury

Risks and Safety

   Both treatments must be performed by qualified professionals.

   Mesotherapy side effects are usually mild—swelling, redness, or bruising.

   Mesolipo can have stronger side effects like prolonged swelling, numbness, or, rarely, skin injury if done incorrectly.

   Correct injection depth and anatomical knowledge are crucial for Mesolipo, especially when using deoxycholic acid.

Which One Should You Choose?

If the goal is better skin, hydration, or hair regrowth → choose traditional mesotherapy.

If the goal is reducing excess fat in small areas with minimal recovery time→Mesolipo injections are the right choice.

Both require multiple sessions for best results.

Always confirm the product's ingredients and safety approvals in your country.

Mesolipo is a focused form of mesotherapy. While both use similar injection techniques, their goals are different—one works on skin quality, the other on fat reduction. For professionals, understanding the distinction is key to choosing the right approach for each client. For clients, it sets clear expectations and keeps safety first. With the right product and skilled application, both can deliver impressive, lasting results. If you're a clinic or practitioner looking for trusted, high-quality Mesolipo solutions, our selected products are designed to meet professional standards and client satisfaction. Get your quote!