Hyaluronic acid filling, what do we inject in?

Hyaluronic acid anti-aging, correction of frontal defects, has become a routine item of major medical aesthetic institutions and hospitals, and now girls who love beauty. So what is the hyaluronic acid injected into our face? How does it work? Is it hurting us? Since 1934, when Meyer, a professor of ophthalmology at Columbia University in the United States, first isolated hyaluronic acid from the vitreous body of a bull's eye, and Carl Meyer's laboratory clarified the chemical structure of hyaluronic acid in the 1950s, that is, a high-molecular-weight linear mucopolysaccharide formed by repeated alternation of disaccharide units D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid is successively extracted from animal tissues such as chicken cobs and bull's eye vitreous, as well as by microbial fermentation.

HA in its natural state, which is quickly absorbed in the body, also does not have good biomechanical properties. Apparently not used to address wrinkles and aging.

However, there are two major functional groups in the HA long-chain molecules: carboxyl groups and hydroxyl groups, which make it possible to enhance the biomechanical properties of HA with chemical modifications, that is, crosslinked hyaluronic acid. The crosslinked HA molecules, entanglement, form a network structure, and the molecular weight is so large that it is almost impossible to measure. From the liquid to a lumpy gel state. It is granulated by the manufacturer to make gel particles suitable for the passage of the injection needle.