Botulinum toxin type A, based on the popular American brand, is an injection that helps reduce facial lines and wrinkles. In terms of cosmetic procedures, it is most commonly used on smile lines, forehead wrinkles, and crow's feet. The active ingredient of botulinum toxin is a purified substance derived from a bacteria called clostridium botulinum. When injected into the muscle, it blocks nerve signals to prevent muscles from contracting. Most effects last anywhere from three to twelve months depending on which area of the face is being treated.
South Korea has emerged as one of the global leaders in the development and production of Botulinum Toxin. With a wide variety of products available at different price points, the options can feel overwhelming for clinics, distributors, and even professionals just starting out.
When choosing a Botulinum Toxin brand, it's essential to understand not only the available formulations but also their unique advantages. For example, among the most recognized and successful Korean brands are Nabota and Botulax, both of which have already obtained U.S. FDA approval, a strong testament to their quality and safety. Another standout is Innotox, known as the world's first pre-diluted (liquid) Botulinum Toxin Type A. Unlike traditional formulations, Innotox does not require reconstitution with saline before injection, making the process quicker, simpler, and more convenient.
Of course, there are many other high-quality Korean Botulinum Toxin brands with their own strengths. In this guide, we'll take a closer look at Nabota, Botulax, ReNTox, Meditoxin, Hutox, and SOTORIOR—all of which offer comparable levels of quality, safety, and effectiveness. Their main differences lie in branding, market positioning, and overall popularity.
Let's explore what makes each of these top Korean Botulinum Toxin brands unique, so you can find the right fit for your practice or business.
Nabota 100U 200U is a botulinum toxin type A product developed by South Korean manufacturer Daewoong. It is a highly purified product which has been manufactured using a patented process to insure that the highest extent of impurities have been removed. Nabota 100U is safe, all-natural, FDA-approved, and easy to use. This product is recommended for adults aged between 20 and 65 years old.Nabota 100U is commonly used for treating Glabella Lines, vertical lines that appear between the eyebrows.
Nabota ingredients include 100 units of clostridium botulinum toxin type A (standard), serum albumin (vitality), and sodium chloride (USP). It is a white or light yellow color lyophilzate packaged in a transparent vial. It becomes transparent when dissolved with a saline solution of 0.9%. To store Nabota in your home, keep it tightly sealed and stored at 2-8 degrees celsius. Do not be alarmed if your vial looks empty. White powder can be seen at the bottom of the vial which needs to be dissolved with saline.
Nabota has purity as hioh as 99%, and producing antibodies in this instace is not easy, It offers a guick effect, and results are visible in two to three days, while for Botulax, the results appear in three to seven days. The overall impact of Nabota lasts for three to six months, depending on how the skin responds. On the other hand, Botulax lasts for six to nine months.
Nabota is more suitable for individuals who have underaone multipte iniection administrations of botulinum toxin and have stopped responding to other brands comprising botulinum toxin.
Botulax 100u is a botulinum toxin type A product developed by South Korean manufacturer Hugel. The mechanism of action of the product is based on the ability of botulinum toxin type A to block the transmission of nerve impulses. Intramuscular administration of the toxin disrupts the synthesis of acetylcholine (a neurotransmitter that ensures neuromuscular conduction) and leads to temporary paralysis of the facial muscles. Frozen facial expressions help relax muscles and smooth wrinkles.
In recent years, Botulax has gained increased global attention. Notably, in 2023, Hugel received FDA approval for its botulinum toxin under the name Letybo, marking a major step toward entering the U.S. aesthetics market. This milestone highlights the product's proven safety, efficacy, and manufacturing standards. With its growing international recognition and strong clinical performance, Botulax continues to be a trusted choice for aesthetic practitioners around the world.
Botulax ingredients include 100 units of clostridium botulinum toxin A type (strain: clostridium botulinum CBFC26), a stabilizer (human serum albumin), and a tonic adjuster (sodium chloride). To store Botulax in your clinic, keep the product sealed and stored between 2-8 degrees celsius. Be sure to use the product 36 months from the date of manufacture.
There is a small amount of white powder at the bottom that needs to be dissolved with saline before use. Typically, dilute 100 units with 2.5 ml of saline, and 200 units with 5 ml, following standard reconstitution guidelines.(see: Botulax Dilution Chart).
Botulax 100units has excellent patient tolerance, meaning it is hypoallergenic, evoking zero negative reactions from the skin. It is free from harmful additives like stabilizers, preservatives, and harmful chemicals. Botulax 100 units come in the form of a homogenous powder that minimizes penetration, distribution, and pain. Size of toxin complex is minimize spread of botulinum toxin outside of the injection site and ensures precise and uniform effect at the time of injection.
Botulax helps to minimize facial wrinkles, muscle spasms, hyperhidrosis, and blepharospasm. Botulax can also be used for improving glabellar wrinkles. Results can be seen from two days following the injection. BOTULAX, which is suitable for patients who want a long-lasting result while not care too much about its slower effect. Usually the duration of effect can reach 4-7 months.
Rentox Botulinum Toxin price 100 units is an innovative drug (botulinum toxin) type A premium class, developed by the South Korean company Pharma Research Bio. It is presented as a lyophilized white powder for injection in a colorless transparent vial. Rentox temporarily paralyze muscle to reduce the appearance of facial wrnkles. Rentox is one of the most safe, effective treatment for fine lines and wrinkles, such as the wrinkles on the forehead, between the eyebrows, on the nose and eyes, "purse wrinkles", omitted corners of the mouth. And Re N Tox also treatment blepharospasm and hyperhidrosis (excessive sweating).
Re N Tox 100 units ingredients include 100u clostridium botulinum toxin type A, Human serum albumin 0.5mg, and Sodium chloride 0.9mg. The improved formula of the Rentox preparation does not contain proteins, albumin, gelatin compared to other botulinum toxins. It is a white color lyophilzate packaged in a transparent vial. It becomes transparent when dissolved with a saline solution of 0.9%. To store RENTOX in your clinic, keep it tightly sealed and stored at 2-8 degrees celsius.
The effect of Rentox is noticeable already 3 days after the procedure, the duration of action is 6-8 months. Re N Tox has a lower diffusion compared to similar products, which allows you to affect local areas of the skin. This is due to its great popularity in cosmetology clinics in South Korea and Japan.
Innotox 50 units is the world's first newly developed liquid injectable form of botulinum toxin type A developed by the South Korean company Medytox Inc, which was approved by the KFDA in Korea in 2013. Unlike conventional botulinum toxins that require reconstitution, Innotox is supplied in a pre-diluted, liquid form, making it easier and faster to use in clinical settings. Its advanced formulation is free from animal-derived ingredients such as human serum albumin, gelatin, and other proteins, significantly reducing the risk of allergic reactions.
In recent years, Innotox has gained increased attention globally. In 2022, Medytox announced ongoing efforts to obtain U.S. FDA approval for Innotox, aiming to enter the American aesthetics market in collaboration with Hugel America and Evolus Inc. Additionally, in 2023, Innotox achieved regulatory approvals in several Asian and Latin American countries, further expanding its global footprint. Thanks to its convenience, safety profile, and long-lasting results, Innotox continues to be a popular choice among medical aesthetics professionals worldwide.
Innotox 50U is a ready-to-use sterile liquid with a concentration of 4U/0.1ml. It can avoid the risk of excessive injection of botulinum toxin or contamination caused by improper ratio of normal saline. Innotox botulinum toxin ultimately improve the safety and efficacy of treatment. In addition, it is more convenient to store and reuse. The new botulinum toxin developed by Innotox extracted from plant protein is less sensitive to temperature than the botulinum toxin extracted from human albumin, so it is more convenient to transport and store. Innotox has long-term stability and can be used for 36 months under storage conditions of 2 to 8 degrees. Innotox is much easier to ship than other brands such as Bolutax.
Innotox is intended for eliminating wrinkles caused by spasticity of muscles or active mimics. It removes lines and folds in the areas of eyes, between the eyebrows, forehead, around the mouth. face wrinkles, jaw muscle, and face lifting.
Meditoxin is a face-lifting botulinum toxin owned by Medytox. It is divided into 100 unit model and 150 unit , 200u. Meditoxin 200u is a prescription-only product based on the Clostridium botulinum family of Botulinum Toxins, It is presented as a lyophilized white powder for injection. It delivers treatment effects that last for up to 6 months and become noticeable within 3 to 6 days after the injection procedure. It serves as a non-surgical solution for adult patients who seek treatment that will temporarily correct and remove signs of aging (particularly moderate to severe glabellar lines).
Meditoxin are also very similar to the American Botulinum Toxin , both in therapeutic action and in their composition. But there is also a difference. It lies in the rather low degree of permeability of Meditoxin into the surrounding tissues. Due to its low diffusion, Meditoxin can be used in delicate areas. For example, in the area of the eyes or lips. The botulinum toxin included in the formulation of Meditoxin has a high molecular weight. Thanks to Meditoxin, it is possible to work out areas with small mimic wrinkles.
For use, dilute the powder in the ampoule with saline. For 100 units, add 2.5 ml of saline, for 200 units - 5 ml of saline. A noticeable result is achieved after 1-2 days after the injection. Due to the low degree of diffusion into the surrounding tissues, complete clinical safety for the body is achieved. Meditoxin have a mild and correct effect without pain and discomfort after the procedure. Meditoxin are also great for treating excessive sweating or hyperhidrosis.
Originated from clostridium botulinum, Sotorior Botulinum toxin type A is produced by innovative Vacuum Drying process for 99% superior purity. SOTORIOR ingredients include 100 units of clostridium botulinum toxin type A, Human serum albumin 0.5mg, and Sodium chloride 0.9 mg. To store Sotorior, keep it tightly sealed and stored at 2-8 degrees celsius. When using Sotorior, dilute 100U/2.5 ml(4U/0.1 ml) with 0.9% sterile saline without preservative.
Since botulinum toxin itself cannot be frozen, the freeze-drying method process often requires a large amount of excipients to stabilize the toxin—resulting in a visibly larger amount of powder in the vial. However, Sotorior botulinum toxin is produced using a vacuum drying method with minimal excipients, unlike many other brands that rely on freeze drying.
In contrast, Sotorior is dried under reduced pressure (vacuum drying), which preserves the integrity of the toxin and significantly reduces the need for additional excipients. As a result, the powder in the vial appears minimal, but the purity and stability of the botulinum toxin are much higher.
Sotorior, developed by Dermax, features advanced drying technology and high purity, delivering reliable performance comparable to leading botulinum toxin products.
Sotorior helps to minimize facial wrinkles, muscle spasms, hyperhidrosis, and blepharospasm. Hyperhidrosis is excessive sweating including outside of excessive heat or exercise. Blepharospasm refers to abnormal contraction of the eyelids. Botulax can also be used for improving glabellar wrinkles. sotorior is particularly suitable for repeated treatments. It delivers treatment effects that last for 4 to 6 months and become noticeable within72 hours after the injection procedure.
Hutox 100 units is another analogue of Botulinum Toxin from the South Korean manufacturer Huon's Global, which is quickly gaining its popularity in the markets of a large number of countries and for good reason. Hutox is a Clostridium botulinum type A toxin with a high purity of 99.8%. This level is considered a new quality standard in the world market. Hutox is a peripherally acting muscle relaxation and provides long-term wrinkle correction.
Hutox is designed to improve moderate, heavy, and deep muscle lines associated with the brow muscles and active facial muscles in adults. In addition to being an anti-aging product, Hutox is used by doctors for problems such as spasticity in the muscles of the legs or arms, and even for patients with hand deformities.
The main advantages of Hutox include a quick and noticeable effect of the procedure, its long-term effect, as well as a loyal cost.
Dermax Botulinum Toxin Comparison
Brands | Botulax | Meditoxin | Nabota | Hutox | Rentox | Innotox |
Duration | 6-9 months | 4-6 months | 3-6 months | 3-6 months | 3-6 months | 3-6 months |
Unit in Stock | 100u 200u | 100u 150u | 100u | 100u | 100u | 50u |
Features | 100u is for thin face, 200u is for calf muscles slimming. The duration is longer, but wait-for-effect is a little long, nearly half a month, relatively mild and stable. Effective and more suitable for wrinkle removal. | The effect of meditoxin is stronger and the effect is quick, but it does not last longer than Botulax. | It is more suitable for people who have had multiple injections of botulinum toxin. The purity is very high and it is not easy to produce antibodies. | Go into effect quickly， highly purified composition | Cost-effective | Liquid Ready-to-inject Easy to storage |
Storage | 2-8° in refrigerator | 2-8° in refrigerator | 2-8° in refrigerator | 0°~4° in refrigerator | 2-8° in refrigerator | Room Temperature |
Price(details please contact dermax) | $65 | $65 | $65 | $57 | $32 | $35 |
Over the past several decades, countless new Botulinum Toxin products have come onto the market. These range from popular brands such as Botulax, Sotorior, , Vistable, and Azzalure, to name a few. The long list of available options can be overwhelming, and with each practitioner using a different brand, it can be difficult to know which product is best for you. On top of this, you may have heard negative stories about a particular product or seen poor results in-person.
That being said, each brand of Botulinum Toxin does the same job despite different names. If the correct dosage is applied and proper care is given during the procedure, each brand should achieve the same, lasting result. Therefore, it is a misconception that a particular brand of Botulinum Toxin will result in a botched appearance. All errors come down to the practitioner as opposed to the item.
Using Botulinum Toxin can result in aesthetic and confidence-boosting looks. It is a very positive cosmetic procedure that, when the correct dose is administered, will reward patients with a symmetrical, natural, and more youthful appearance. In short, Botulinum Toxin is safe and reliable. Any faulty result simply comes down to an incorrect dosage. Know more about korean botulinum toxin brands products information,Contact Us as soon as possible.
With nearly 20 years of expertise in medical aesthetics, Dermax is a trusted name in the development, production, and global distribution of premium aesthetic products. We specialize in botulinum toxin, PDO threads, hyaluronic acid fillers, skin boosters, and microcannulas, backed by a GMP-certified facility, a professional R&D team, and a strict quality control system.
Dermax owns well-known brands such as Sotorior®, Magik Thread®, Aqua Secret®, and CozySculpt®, and also supplies popular aesthetic solutions including Lipolab, Liporase, and skin whitening injections. Our product portfolio covers HA fillers for lips, cheeks, and breasts, PLLA fillers for the neck, hands, and stretch marks, fat-dissolving injectables, and hybrid HA+PLLA fillers—designed to meet the evolving needs of aesthetic clinics, med spas, and professionals worldwide.
To support our international clients, Dermax work with FEDEX, DHL, UPS and other couriers to ensure the fastest and guaranteed delivery, and smooth order fulfillment. We also offer dedicated after-sales service, providing professional support and timely solutions to help our partners maintain high customer satisfaction.
With certified products, competitive pricing, and a proven global distribution network, Dermax helps partners succeed in both business and beauty.
If yo're exploring options like Botulax, Nabota, etc., or looking for a reliable, full-service supplier—contact us today for expert advice and top-quality products.
