what to do if botulinum toxin systemic poisoning

Views: 1     Author: Site Editor     Publish Time: 2022-09-09      Origin: Site

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Botulinum toxin poisoning is mostly an acute poisoning disease caused by eating food containing botulinum toxin. Under normal circumstances, botulinum toxin injections for cosmetic purposes will not lead to systemic botulinum toxin poisoning, but due to some illegal botulinum toxin products in some unhealthy beauty salons, studios, and even private doctors, the concentration and efficacy of botulinum toxins are not known. The price cannot be determined. What do you think will happen if irregular doctors use irregular injection methods in irregular places? Therefore, in recent years, there have been many reports of acute systemic botulinum toxin poisoning caused by cosmetic injections across the country.

Common symptoms of systemic botulinum toxin poisoning are headache, dizziness, general weakness, difficulty in raising head and limbs, diplopia, strabismus and blurred vision, difficulty breathing, dysphonia, inability to chew, choking on drinking water and difficulty swallowing, difficulty urinating and defecation Wait.


1. Botulinum antitoxin is currently the only effective drug for the treatment of botulinum toxin poisoning. All botox Toxin

Botulinum antitoxin is a class of botulinum toxin-neutralizing agents obtained from immunized animals using botulinum toxoid for the prevention and treatment of botulinum toxin poisoning. According to the botulinum toxin antigen type, botulinum antitoxin can be divided into three types: type A, type B, and type E. The A type in each 1ML shall not be less than 1000U, and the B type and E type shall not be less than 6000U (the antitoxin titer test is usually based on the amount that can neutralize 100IU of the toxin as 1 antitoxin unit).


Anyone who has symptoms of botulinum toxin poisoning should be treated with botulinum toxin as soon as possible, and botulinum antitoxin should be used for prevention as soon as possible for suspected poisoning. Clinically, most of the botulinum toxin poisoning is type A, and very few are type B. When the toxin type has not been determined, two types of antitoxin are used.

Although botulinum antitoxin can be used for the treatment of acute poisoning due to overdose of botulinum toxin injection, after 1 day of injection or more, it is difficult to get close to the antitoxin after internalization, and has blocked acetylcholine, resulting in clinical adverse reactions. Injecting antitoxins will be much less effective, so the earlier the use of botulinum antitoxins, the better.

It can occur suddenly during the injection or within minutes to tens of minutes after the injection. Sudden symptoms of dullness or irritability, paleness or flushing, chest tightness or panting, cold sweats, nausea or abdominal pain, rapid pulse, decreased blood flow, coma and collapse in severe cases, may lead to rapid death if not forced in time. Mild cases can be relieved after injection of epinephrine; severe cases require fluid infusion, oxygen infusion, use of vasopressors to maintain blood pressure, and use of anti-allergic drugs and adrenal corticosteroids for rescue.


The main symptoms of serum sickness are urticaria, fever, lymphadenopathy, local edema, and occasionally proteinuria, vomiting, arthralgia, and erythema, itching, and edema at the injection site. Most of the onset occurs 7 to 14 days after injection, which is called delayed type; a few patients have onset 2 to 4 days after injection, which is called accelerated type. For symptomatic treatment of serum sickness, calcium or antihistamine drugs can be used, and it can usually be cured within a few days to ten days.


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