Author: Site Editor Publish Time: 10-11-2025 Origin: Site
What are polynucleotides under eyes? Tired eyes often betray more than just fatigue—they can reveal dehydration, collagen loss, and cellular damage beneath the skin’s surface. Traditional solutions like fillers and lasers can be effective, but bring trade-offs such as unnatural volume, treatment downtime, or only superficial results. This has fueled interest in a regenerative alternative: polynucleotide under-eye injections.
By promoting natural tissue repair and enhancing hydration from within, PNs target the root causes of under-eye dullness and fine lines rather than simply masking them. For aesthetic professionals and patients seeking non-filler rejuvenation, polynucleotides stand out as a science-backed method for lasting under-eye revitalization.
Polynucleotides (PNs) are long chains of nucleic acids—the molecular building blocks of DNA and RNA. In aesthetic medicine, PNs used for skin rejuvenation are typically extracted from biological sources and subjected to high‑grade purification to remove proteins and other impurities.
Clinically formulated PNs differ from simple fillers. Their principal action is biologically modulatory rather than purely volumizing. At the molecular level, PNs function in three complementary ways:
· Cellular signalling: PNs act as biological cues that help ‘re‑educate’ dermal fibroblasts. Exposed to these cues, fibroblasts can increase endogenous synthesis of extracellular matrix components including collagen (predominantly types I and III), elastin, and native hyaluronic acid.
· Hydration and osmotic support: High‑molecular‑weight PNs can bind water and help retain moisture within the deep dermis, producing early improvements in skin turgor and texture.
· Tissue repair and microcirculation: By modulating local inflammatory processes and supporting microvascular health, PNs contribute to a more favourable environment for tissue remodelling and improved skin clarity.
Formulations intended for periorbital use are typically engineered with higher molecular weight fractions and careful purification to minimize local irritation. Clinical concentrations commonly fall near the mid‑single digits to low double‑digit mg/mL range, depending on the product and intended indication.
The periorbital skin is the thinnest on the body, richly supplied with capillaries and lymphatics, and subject to constant muscular movement. Those anatomical realities explain why the area shows aging signs early and why aggressive volumizing approaches can be problematic.
Polynucleotides map well to the needs of this delicate zone:
· Regeneration rather than bulk: PNs stimulate dermal remodelling and quality improvement without adding substantial volume, lowering the risk of a puffy or overfilled appearance.
· Improved microcirculation and reduced translucency: By promoting healthier dermal architecture and modulating inflammation, PNs can help reduce the visibility of bluish vascular shadows in some patients.
· Deep hydration from within: PN‑driven hydration improves skin reflectivity and reduces the contrast that accentuates dark circles caused by thin, dehydrated skin.
· Dermal thickening: Over a course of treatments, increased collagen and extracellular matrix deposition can mildly thicken the dermis, helping to mask underlying vasculature and pigment.
These effects make PN therapy a logical complement—or in some cases an alternative—to fillers, particularly where texture and skin quality are the primary concerns.
Consultation and Assessment: A detailed clinical evaluation is essential. The clinician must determine whether the predominant issue is volume loss (where a hyaluronic acid filler may be primary), pigmentation, vascularity, or superficial skin laxity.
Procedure: Periorbital PN treatments are delivered as a series of superficial microinjections (mesotherapy‑style) into the superficial dermis and deep dermis depending on the protocol. Topical anesthesia is commonly used. Very fine needles (e.g., 30–32G) or microcannulas are typical to limit trauma.
Course and Timing: An initial course typically involves 2–3 polynucleotide under-eye sessions, spaced 3–4 weeks apart. Patients often report improved hydration and smoother skin within a few days; more structural improvements—tightness, reduced fine lines, and better tone—tend to emerge over 2–8 weeks as matrix remodeling progresses. Results accumulate with repeated sess
Treatment | Mechanism | Downtime | Primary Benefit | Notes |
Polynucleotides (PNs) | Biological stimulation of dermal remodeling | Minimal | Improves texture, hydration, dermal quality | Best for skin quality and thin‑skin related concerns |
Hyaluronic Acid Fillers | Volumizing; space‑filling | Minimal → Moderate (depends) | Restores volume and contour | Risk of puffiness if overfilled; may be combined with PN to improve skin quality |
Laser / RF Devices | Thermal stimulation of collagen via external energy | Variable; can include erythema/scabbing | Tightening, resurfacing | More aggressive; higher downtime and risks in periorbital area |
Topical Eye Care (Creams) | Surface hydration and antioxidant delivery | None | Maintenance and symptom relief | Limited penetration—cannot remodel deep dermis |
Who Is the Ideal Candidate?
Patients with thin, crepey under‑eye skin, early fine lines, dehydration, or vascular/translucency‑related dark circles are good candidates.
What Are the Side Effects?
Common, mild polynucleotide under eyes side effects include transient redness, swelling, bruising, and occasional small hematomas.
How Many Sessions Are Needed?
A typical initial course is 2–3 sessions, usually spaced 3–4 weeks apart; maintenance every 6–12 months is common.
Are the Results Permanent?
No—PNs promote tissue remodeling but do not permanently alter anatomy. Results are durable for many months, particularly with maintenance, but are not lifelong.
What About Cost?
Costs typically range from $200 to $800+ per session. The final price depends on your location, the clinic's expertise, and the specific product used.
Which Product Should Clinicians Consider?
For the delicate under-eye area, clinicians should select PNPURE™ NeoEye, a high-purity, low-endotoxin polynucleotide (PN) formulation specifically designed for this indication.
For under-eye rejuvenation, polynucleotides offer a fundamental shift from simply adding volume to actively regenerating skin. This approach works by stimulating your body's own collagen, restoring deep hydration, and improving microcirculation for natural-looking results.
The key to success lies in choosing an expert clinician and high-quality products. To determine if this treatment is your ideal solution, we invite you to contact us for a personalized assessment with our expert practitioners.
