Author: Site Editor Publish Time: 09-28-2025 Origin: Site
When it comes to treating dark circles, fine lines, and skin laxity under the eyes, many patients and practitioners are faced with the question: PRP vs polynucleotides under eyes— which option delivers better results? Both treatments aim to rejuvenate delicate under-eye skin, but they differ significantly in mechanism, consistency of results, and long-term benefits. In this article, we’ll break down the comparison and highlight why polynucleotides, particularly PNPURE™ NeoEye, are becoming the preferred choice in under-eye care.
Polynucleotides are biocompatible DNA fragments, often sourced from salmon, that support skin regeneration. They work by stimulating fibroblast activity, improving the extracellular matrix, and enhancing hydration and elasticity.
Key Benefits for Under-Eye Rejuvenation:
Stimulates collagen and elastin for long-lasting structural improvement.
Improves skin tone, reduces pigmentation, and smooths fine lines.
Provides deep hydration and anti-inflammatory effects.
Safe, stable, and consistent across different patients.
Polynucleotides have gained strong clinical evidence and are increasingly recognized as a gold standard in eye-area biostimulation. For patients and clinics seeking the best polynucleotide for under eyes solution, high-purity options like PNPURE™ NeoEye offer outstanding results with proven safety.
PRP, or platelet-rich plasma, is an autologous treatment derived from a patient’s own blood. After drawing blood, it is centrifuged to separate the platelet-rich layer, which is then injected into the under-eye area.
How it works: Platelets contain growth factors that can stimulate tissue repair and collagen production.
Advantages:
100% autologous, minimizing risk of rejection.
Can promote skin healing and mild rejuvenation.
Limitations:
Results vary greatly from person to person due to differences in platelet concentration and activity.
Shorter duration of effect, typically 3–6 months.
Requires blood draw and preparation, making the procedure less convenient.
Feature | PRP | Polynucleotides (PNs) |
Source | Patient’s own blood | Salmon DNA, highly purified |
Procedure | Requires blood draw and centrifugation | Ready-to-use injectable |
Result Consistency | Highly variable | Stable and predictable |
Duration | 3–6 months | 6–12 months or longer |
Effect on Skin | Mild collagen boost, variable pigmentation improvement | Strong collagen & elastin stimulation, hydration, brightening, fine-line reduction |
Suitability | Patients preferring autologous therapy | Broad patient suitability, especially for delicate under-eye concerns |
Polynucleotides address multiple concerns at once: improving hydration, reducing dark circles, softening wrinkles, and restoring elasticity. Unlike PRP, their results are consistent, predictable, and backed by clinical research. For patients seeking reliable and lasting results in the sensitive under-eye region, polynucleotides are the more advanced option.
Among polynucleotide-based injectables, PNPURE™ NeoEye stands out for its advanced formulation and safety profile.
What makes it unique:
√ High molecular weight PN (1260–1570 kDa): Gentle on delicate under-eye skin while delivering powerful regenerative effects.
√ PUNEXT™ purification technology: Ensures >99% purity by removing proteins and impurities, guaranteeing high biocompatibility.
√ Premium source: Derived from Pacific salmon DNA, with a 98% genetic similarity tandard non-crosslinked hyaluronic acid injectables, PNPURE™ NeoEye demonstrates superior fibroblast activation and longer-lasting rejuvenation.
For those struggling specifically with puffiness and discoloration, polynucleotides for under eye bags like PNPURE™ NeoEye provide targeted relief and visible improvement with each session.
PRP: Suitable for patients preferring autologous treatments, or those with mild concerns and lower budgets.
Polynucleotides: Recommended for most patients seeking stable, predictable, and effective solutions for under-eye dark circles, fine lines, and loss of elasticity.
When comparing PRP vs polynucleotides under eyes, both have their place in aesthetic medicine. However, polynucleotides offer a more comprehensive, reliable, and long-lasting solution for under-eye rejuvenation. With advanced products like PNPURE™ NeoEye, clinics and patients can achieve safer, more visible, and sustained improvements.
Looking to elevate your under-eye treatments? Choose PNPURE™ NeoEye for clinically proven, high-purity polynucleotides that deliver natural and lasting results. If you’re interested in our products, click here to contact us.
