Author: Site Editor Publish Time: 11-05-2025 Origin: Site
Clinical-grade skin booster based on polynucleotides — stimulates skin regeneration for improved texture and elasticity. Professional treatment options, clear pricing guidance, and documented before-and-after cases — view our flagship product.
Polynucleotide treatment is rapidly becoming one of the most sought-after regenerative aesthetic solutions. Using highly purified DNA fragments extracted from natural sources, this advanced injectable helps repair damaged skin cells, improve hydration, and restore elasticity from within.
Whether you’re exploring this treatment for facial rejuvenation, acne scars, or overall skin improvement, this guide will walk you through what makes polynucleotide treatment unique—how it works, its benefits, results timeline, cost insights, safety profile, and aftercare essentials. By the end, you’ll have a complete picture of what to expect before deciding if it’s the right choice for you.
Polynucleotide treatment is an innovative regenerative aesthetic procedure designed to restore skin health and vitality at a cellular level. Polynucleotides (PNs) are purified chains of DNA fragments—typically derived from natural sources such as salmon or trout—which have powerful bio-stimulatory effects when injected into the skin.
Once administered, these molecules act as cellular repair agents, stimulating fibroblast activity, enhancing tissue regeneration, and promoting the synthesis of collagen and elastin. The result is skin that gradually becomes firmer, smoother, more hydrated, and more luminous.
Unlike dermal fillers that add instant volume, polynucleotide treatment focuses on skin quality improvement over time. It helps to repair photodamage, reduce fine lines, and improve elasticity—making it an ideal choice for patients seeking a natural, progressive rejuvenation rather than a dramatic change.
Polynucleotide treatments work through a process known as bio-stimulation, where naturally derived DNA fragments trigger the skin’s self-repair and regeneration mechanisms.
When injected into the dermis, polynucleotides:
1. Activate fibroblasts, the skin cells responsible for producing collagen and elastin.
2. Enhance tissue oxygenation, improving overall cellular metabolism and microcirculation.
3. Attract water molecules, creating a deeply hydrated environment that supports healing and elasticity.
4. Neutralize free radicals, thanks to their antioxidant properties, which help slow the skin’s aging process.
Over the following weeks, these biological processes lead to visible improvements—fine lines soften, dullness fades, and the skin gains a youthful glow.
Polynucleotide treatments are designed for individuals seeking gradual, natural skin rejuvenation rather than instant volumization. They are suitable for a wide range of skin concerns and can be tailored to different treatment areas, including the face, neck, décolleté, and hands.
1. Improves Skin Elasticity and Firmness
Stimulates collagen and elastin production, helping skin regain its natural resilience.
2. Enhances Hydration and Skin Quality
Polynucleotides attract water molecules, deeply hydrating the skin for a smoother, more supple texture.
3. Reduces Fine Lines and Early Signs of Aging
Gradually softens wrinkles, especially around eyes, forehead, and nasolabial folds.
4. Supports Skin Repair and Renewal
Accelerates recovery from photodamage, environmental stress, or minor scarring.
5. Promotes a Radiant, Healthy Glow
Improves skin tone and brightness, giving the appearance of fresher, revitalized skin.
· Individuals aged 25–55 looking for early anti-aging solutions.
· Those with dull, dehydrated, or fatigued skin.
· Patients with mild fine lines or early wrinkles.
· Anyone seeking natural skin rejuvenation without dramatic volume change.
Polynucleotide treatments work gradually, stimulating the skin’s natural regeneration process. Unlike hyaluronic acid fillers that provide instant volume, PN treatments deliver subtle, progressive improvements over several weeks.
1. First Week
Minor redness, swelling, or pinpoint bruising may occur at injection sites.
Most patients can resume normal activities immediately.
2. 2–4 Weeks
Early improvements in hydration and skin texture may be noticeable.
Skin appears softer, smoother, and more radiant.
3. 6–8 Weeks
Collagen and elastin production begin to strengthen, enhancing firmness and elasticity.
Fine lines start to soften, and overall skin tone improves.
4. 3–4 Months
Optimal visible results are typically achieved after 2–4 sessions.
Skin looks revitalized with improved elasticity, brightness, and smoothness.
5. Maintenance
Results can last 6–12 months depending on age, skin condition, and lifestyle factors.
Follow-up or booster sessions are recommended to maintain long-term benefits.
Gradual results provide a natural, non-overfilled appearance.
Effectiveness varies depending on skin type, age, and number of sessions.
Patience is required—visible transformation builds over weeks, not days.
The cost of polynucleotide treatments varies depending on factors such as the treatment area, number of sessions, clinic location, and the brand or purity of the product used. Understanding these variables helps patients make informed decisions and set realistic expectations.
Single facial session: $250–$500 USD
Package of 3–4 sessions: $700–$1,800 USD
Special areas (neck, décolleté, hands): Additional $100–$300 per session
> Note: Prices may differ between countries or regions. Clinics in the UK, US, or major cities may charge higher fees compared to smaller clinics.
1. Number of Sessions – More sessions generally lead to better cumulative results.
2. Treatment Area Size – Larger areas require more product and longer injection time.
3. Product Quality and Brand – Premium polynucleotide brands (e.g., Dermax) may cost more but provide consistent results.
4. Clinic Expertise – Experienced practitioners often charge higher fees but ensure safety and optimal outcomes.
Compare packages rather than single-session prices.
Ask if aftercare or follow-up sessions are included.
Consider treatment longevity and effectiveness—gradual, high-quality results may justify higher upfront cost.
For a detailed guide on pricing, see our polynucleotide treatment cost page.
Polynucleotide treatments gradually enhance skin texture, elasticity, and radiance. The images below showcase typical results after 2–4 sessions, highlighting subtle yet noticeable improvements:
Firmer, smoother skin
Reduction of fine lines and early wrinkles
Brighter and more even skin tone
For a closer look at real cases, visit our polynucleotides treatment before and after gallery to see detailed transformations
> Note: Individual results may vary depending on skin type, age, and treatment plan.
Polynucleotide treatments are generally well-tolerated, but minor side effects may occur, as with any injectable procedure. Understanding these helps patients prepare and ensures a safe treatment experience.
Mild redness or swelling at injection sites
Small bruises or pinpoint bleeding
Temporary tenderness or tingling
Rarely, slight itchiness or localized irritation
Most of these effects resolve within a few days and do not affect daily activities.
For a detailed overview, see our polynucleotides treatment side effects page.
Minimal: most patients can resume normal activities immediately.
Avoid heavy exercise, sauna, or direct sun exposure for the first 24–48 hours.
Makeup can usually be applied after 24 hours if desired.
Learn more about recovery and safe practices on our polynucleotide treatment downtime page.
Proper polynucleotide treatment aftercare helps optimize results and minimize risks:
1. Hydration: Keep your skin moisturized to support healing.
2. Sun Protection: Apply sunscreen daily to prevent UV-induced damage.
3. Avoid Aggressive Treatments: Do not use strong chemical peels, laser procedures, or abrasive scrubs for at least a week.
4. Follow Practitioner Instructions: Adhere to any specific advice given during your consultation.
5. Wear light makeup if desired, but avoid heavy products for the first 24 hours.
Get full guidance on aftercare at our polynucleotide treatment aftercare page.
Among the leading brands in polynucleotide treatments, PNPURE™ stands out for its high purity, clinical safety, and consistent results. Derived from Pacific salmon DNA and purified using advanced PUNEXT™ technology, PNPURE™ supports deep skin regeneration, improves hydration, and restores skin structure for a natural, rejuvenated appearance.
1. PNPURE™ NeoSkin
Concentration: 2.5% high-dose PN
Molecular Weight: 1260–1570 kDa
Treatment Area: Full face
Key Benefits:
Supports deep dermal regeneration
Restores elasticity and firmness
Provides intensive hydration
Enhances skin barrier
Improves overall skin tone and texture
2. PNPURE™ NeoEye
Concentration: 1% PN combined with HA, amino acids, and peptides
Molecular Weight: 1260–1570 kDa
Treatment Area: Delicate eye region
Key Benefits:
Hydrates and nourishes sensitive areas
Enhances elasticity and tightness
Provides antioxidant defense for brighter, healthier-looking eyes
Both products work by stimulating fibroblast activity, promoting collagen and elastin production, and improving skin quality from within. Clinical studies show that PNPURE™ offers longer-lasting results and superior skin improvement compared with standard non-crosslinked hyaluronic acid, making it an ideal choice for both practitioners and patients seeking high-quality polynucleotide treatments.
1. How many sessions do I need?
Most patients achieve optimal results after **2–4 sessions**, spaced 3–4 weeks apart. Maintenance sessions may be scheduled every 6–12 months depending on skin condition and desired longevity.
Learn more about how many polynucleotide treatments you might need.
2. Is the treatment painful?
Discomfort is minimal, as fine needles or microcannulas are used. Topical numbing can be applied if needed. Most patients describe the procedure as tolerable.
3. Can treatments be combined with other skin procedures?
Yes, polynucleotide treatments can often be combined with treatments like hyaluronic acid fillers, botulinum toxin, or laser therapy. Your practitioner will design a schedule to maximize results while ensuring safety.
4. Is polynucleotide treatment suitable for all skin types?
Polynucleotide treatments are generally safe for most skin types. Patients with active skin infections or severe chronic conditions should consult a dermatologist before treatment.
5. How long do the effects last if I stop maintenance sessions?
Without follow-up sessions, results gradually diminish over 6–12 months, depending on age, lifestyle, and skin condition. Some subtle improvements may persist longer due to enhanced collagen and elastin production.
6. Can I see immediate results after the first session?
While some hydration and skin plumpness may be noticeable, most visible improvements in firmness, elasticity, and texture appear gradually over 2–3 months.
7. Are polynucleotide treatments safe during pregnancy or breastfeeding?
Polynucleotide injections are not recommended during pregnancy or breastfeeding. Consult your physician for alternative skin care options during this period.
