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PNPURE™
PNPURE™ is a clinically oriented polynucleotide filler engineered to restore skin structure from within. As a premium polynucleotide filler series, PNPURE™ combines high-molecular-weight polynucleotides with formulation science to rebuild dermal matrices, deliver deep hydration, and improve resilience with a safety profile suitable for aesthetic clinics and discerning patients.
Polynucleotide-based treatments represent a shift from simple volumization toward regenerative support. Unlike purely volumizing implants, a polynucleotide filler acts as a biologically compatible scaffold and signaling substrate in the dermis. This approach promotes fibroblast activity, extracellular matrix remodeling, and gradual restoration of native collagen and elastin — producing natural-looking improvements in texture, tone, and firmness rather than transient swelling.
PN Concentration: 25 mg/mL
Molecular Weight Range: 1260–1570 kDa
Presentation: 3 mL Prefilled Syringe (30G Needle)
Indication: Whole-Face Dermal Rejuvenation, Skin Laxity, Structural Support, Post-Procedure Recovery
NeoSkin is formulated for practitioners who want a high-dose regenerative option. The elevated polynucleotide content and large molecular size form a robust three-dimensional matrix within the dermis, supporting deeper and longer-lasting stimulation of tissue repair pathways. Clinically this translates to improved dermal density, sustained hydration, and progressive tightening over repeated sessions.
PN Concentration: 10 mg/mL
Molecular Weight Range: 1260–1570 kDa
Presentation: 1 mL Prefilled Syringe (30G Needle)
Indication: Delicate Eye-Area Rejuvenation, Fine Lines, Dehydration, Thin-Skin Reinforcement
NeoEye blends polynucleotides with complementary actives — hyaluronic acid, selected amino acids, and creatine — to provide multi-modal support where tissues are thin and sensitive. The result is targeted improvement in elasticity and hydration with minimized irritation risk.
PNPURE™ polynucleotide filler starts with carefully selected Pacific salmon DNA harvested from cold, low-contaminant waters near 35°N latitude. This raw material offers high sequence compatibility with human tissue and a naturally low impurity burden. Our aquaculture and sourcing protocols emphasize antibiotic-free, sterile conditions to ensure consistency of biological material.
The biological material undergoes PUNEXT™ Multi-Stage Purification, a process designed to remove residual proteins, endotoxins, and low-molecular-weight impurities. Only polynucleotide fractions meeting a strict >99% purity threshold are used in PNPURE™ formulations. This combination of controlled sourcing and rigorous purification supports predictable clinical performance and excellent biocompatibility.
1. Scaffold Formation: High-molecular-weight PN deposits in the dermis to form a hydrated, viscoelastic micro-matrix that supports cellular migration.
2. Cellular Activation: PN molecules modulate local cell signaling, encouraging fibroblast proliferation and increased synthesis of collagen and elastic fibers.
3. Extracellular Matrix Remodeling: Over weeks, newly synthesized matrix components restore dermal thickness and tensile properties.
4. Functional Hydration: PN’s hygroscopic properties and complementary HA (in NeoEye) improve interstitial water retention, reducing fine lines and crepiness.
These steps produce both immediate improvement in skin texture (within days) and progressive structural gains (over weeks) that continue after treatment completion.
Initial Session: Visible smoothing and hydration often noticed within 2–4 days.
After Second Treatment (2–3 Weeks): Increased firmness and reduction in superficial lines as fibroblast-driven remodeling progresses.
Cumulative Benefit (After 3–4 Sessions): Noticeable improvement in lift, volume normalization, and sustained radiance as dermal architecture strengthens.
Protocols vary by indication; full-face rejuvenation with NeoSkin typically follows a series of 3–4 sessions spaced 2–4 weeks apart, while NeoEye protocols prioritize conservative volumes with the same interval to minimize local edema.
Comparative histology and in vitro data indicate that high-purity, high-molecular-weight polynucleotides more effectively stimulate fibroblast proliferation and matrix deposition than sd non-crosslinked hyaluronic acid in regenerative endpoints. PNPURE™’s formulation focus on purity, molecular size, and targeted co-actives (in NeoEye) aims to deliver both rapid symptomatic relief (hydration, smoother texture) and durable structural rejuvenation.
Safety monitoring in clinical use demonstrates low rates of adverse events when administered by trained professionals using proper aseptic technique and injection planes.
Indications: Skin Laxity, Fine Lines, Poor Skin Texture, Post-Procedural Dermal Support, And Periocular Dehydration.
Contraindications: Active Infection At The Injection Site, Known Hypersensitivity To Any Component, Or Conditions Where Wound Healing Is Impaired.
Practitioner Tips: Microdroplet or linear threading techniques in the mid-to-deep dermis optimize matrix integration; avoid intravascular placement. Conservative dosing in the periocular area reduces transient edema.
PNPURE™ polynucleotide filler is supplied in sterile, single-use prefilled syringes optimized for clinic workflow. We maintain regional distribution centers to shorten lead times and support bulk procurement. Our pricing strategy focuses on affordability for clinics and institutions — competitive unit pricing with additional discounts for volume orders and long-term partnerships.
Regenerative Focus: Moves beyond short-lived volumization to restore native tissue properties.
High-Purity Chemistry: Reduces immunogenic burden and supports predictable outcomes.
Two Targeted SKUs: Clinically practical options for full-face and sensitive periocular indications.
Cost-Effective Procurement: Enables clinics to adopt advanced regenerative protocols without prohibitive capital outlay.
We provide detailed administration protocols, patient selection checklists, and post-care guidance to support safe and effective integration of PNPURE™ polynucleotide filler into practice. Training modules and technical support are available for purchasing partners.
Contact your Dermax representative for pricing, clinical datasheets, and bulk-order terms.
PNPURE™ polynucleotide filler is intended for use by licensed medical professionals. This product information summarizes formulation and clinical rationale for professional evaluation and does not replace product labeling or regulatory documentation.
PNPURE™ is a clinically oriented polynucleotide filler engineered to restore skin structure from within. As a premium polynucleotide filler series, PNPURE™ combines high-molecular-weight polynucleotides with formulation science to rebuild dermal matrices, deliver deep hydration, and improve resilience with a safety profile suitable for aesthetic clinics and discerning patients.
Polynucleotide-based treatments represent a shift from simple volumization toward regenerative support. Unlike purely volumizing implants, a polynucleotide filler acts as a biologically compatible scaffold and signaling substrate in the dermis. This approach promotes fibroblast activity, extracellular matrix remodeling, and gradual restoration of native collagen and elastin — producing natural-looking improvements in texture, tone, and firmness rather than transient swelling.
PN Concentration: 25 mg/mL
Molecular Weight Range: 1260–1570 kDa
Presentation: 3 mL Prefilled Syringe (30G Needle)
Indication: Whole-Face Dermal Rejuvenation, Skin Laxity, Structural Support, Post-Procedure Recovery
NeoSkin is formulated for practitioners who want a high-dose regenerative option. The elevated polynucleotide content and large molecular size form a robust three-dimensional matrix within the dermis, supporting deeper and longer-lasting stimulation of tissue repair pathways. Clinically this translates to improved dermal density, sustained hydration, and progressive tightening over repeated sessions.
PN Concentration: 10 mg/mL
Molecular Weight Range: 1260–1570 kDa
Presentation: 1 mL Prefilled Syringe (30G Needle)
Indication: Delicate Eye-Area Rejuvenation, Fine Lines, Dehydration, Thin-Skin Reinforcement
NeoEye blends polynucleotides with complementary actives — hyaluronic acid, selected amino acids, and creatine — to provide multi-modal support where tissues are thin and sensitive. The result is targeted improvement in elasticity and hydration with minimized irritation risk.
PNPURE™ polynucleotide filler starts with carefully selected Pacific salmon DNA harvested from cold, low-contaminant waters near 35°N latitude. This raw material offers high sequence compatibility with human tissue and a naturally low impurity burden. Our aquaculture and sourcing protocols emphasize antibiotic-free, sterile conditions to ensure consistency of biological material.
The biological material undergoes PUNEXT™ Multi-Stage Purification, a process designed to remove residual proteins, endotoxins, and low-molecular-weight impurities. Only polynucleotide fractions meeting a strict >99% purity threshold are used in PNPURE™ formulations. This combination of controlled sourcing and rigorous purification supports predictable clinical performance and excellent biocompatibility.
1. Scaffold Formation: High-molecular-weight PN deposits in the dermis to form a hydrated, viscoelastic micro-matrix that supports cellular migration.
2. Cellular Activation: PN molecules modulate local cell signaling, encouraging fibroblast proliferation and increased synthesis of collagen and elastic fibers.
3. Extracellular Matrix Remodeling: Over weeks, newly synthesized matrix components restore dermal thickness and tensile properties.
4. Functional Hydration: PN’s hygroscopic properties and complementary HA (in NeoEye) improve interstitial water retention, reducing fine lines and crepiness.
These steps produce both immediate improvement in skin texture (within days) and progressive structural gains (over weeks) that continue after treatment completion.
Initial Session: Visible smoothing and hydration often noticed within 2–4 days.
After Second Treatment (2–3 Weeks): Increased firmness and reduction in superficial lines as fibroblast-driven remodeling progresses.
Cumulative Benefit (After 3–4 Sessions): Noticeable improvement in lift, volume normalization, and sustained radiance as dermal architecture strengthens.
Protocols vary by indication; full-face rejuvenation with NeoSkin typically follows a series of 3–4 sessions spaced 2–4 weeks apart, while NeoEye protocols prioritize conservative volumes with the same interval to minimize local edema.
Comparative histology and in vitro data indicate that high-purity, high-molecular-weight polynucleotides more effectively stimulate fibroblast proliferation and matrix deposition than sd non-crosslinked hyaluronic acid in regenerative endpoints. PNPURE™’s formulation focus on purity, molecular size, and targeted co-actives (in NeoEye) aims to deliver both rapid symptomatic relief (hydration, smoother texture) and durable structural rejuvenation.
Safety monitoring in clinical use demonstrates low rates of adverse events when administered by trained professionals using proper aseptic technique and injection planes.
Indications: Skin Laxity, Fine Lines, Poor Skin Texture, Post-Procedural Dermal Support, And Periocular Dehydration.
Contraindications: Active Infection At The Injection Site, Known Hypersensitivity To Any Component, Or Conditions Where Wound Healing Is Impaired.
Practitioner Tips: Microdroplet or linear threading techniques in the mid-to-deep dermis optimize matrix integration; avoid intravascular placement. Conservative dosing in the periocular area reduces transient edema.
PNPURE™ polynucleotide filler is supplied in sterile, single-use prefilled syringes optimized for clinic workflow. We maintain regional distribution centers to shorten lead times and support bulk procurement. Our pricing strategy focuses on affordability for clinics and institutions — competitive unit pricing with additional discounts for volume orders and long-term partnerships.
Regenerative Focus: Moves beyond short-lived volumization to restore native tissue properties.
High-Purity Chemistry: Reduces immunogenic burden and supports predictable outcomes.
Two Targeted SKUs: Clinically practical options for full-face and sensitive periocular indications.
Cost-Effective Procurement: Enables clinics to adopt advanced regenerative protocols without prohibitive capital outlay.
We provide detailed administration protocols, patient selection checklists, and post-care guidance to support safe and effective integration of PNPURE™ polynucleotide filler into practice. Training modules and technical support are available for purchasing partners.
Contact your Dermax representative for pricing, clinical datasheets, and bulk-order terms.
PNPURE™ polynucleotide filler is intended for use by licensed medical professionals. This product information summarizes formulation and clinical rationale for professional evaluation and does not replace product labeling or regulatory documentation.
