Author: Site Editor Publish Time: 09-08-2025 Origin: Site
The delicate skin around the eyes is one of the first areas to show signs of aging, fatigue, or environmental stress. Polynucleotide(PN) treatment under eye has emerged as a highly specialized approach to rejuvenate this sensitive region by stimulating natural skin repair, enhancing elasticity, and improving hydration. Unlike general facial treatments, periocular PN therapy requires careful consideration of anatomy, tissue thickness, and vascular structures to ensure both safety and optimal results.
Modern formulations, such as PNPURE™ NeoEye pn skin booster, are specifically designed for under-eye applications. By combining high-purity polynucleotides with hyaluronic acid, amino acids, and carnosine, this treatment helps reduce dark circles, smooth fine lines, and restore skin brightness, while keeping irritation to a minimum. Its targeted design makes it an advanced option for patients seeking safe and effective under-eye rejuvenation.
The under-eye region is distinct from other facial areas due to its thin dermis, reduced fat padding, and rich vascular network. These characteristics make it prone to visible aging signs as well as treatment-related complications if not handled with precision. PN treatment under eye is particularly indicated for:
Dark circles caused by thinning skin and reduced microcirculation.
Fine lines and early wrinkles resulting from collagen and elastin loss.
Loss of elasticity leading to mild skin laxity in the lower eyelid area.
Texture irregularities such as roughness or early pigmentation changes.
Because periocular skin is significantly thinner than the rest of the face, conventional injectables often carry a higher risk of swelling or lump formation. Polynucleotides, by contrast, provide a gentler regenerative effect, encouraging fibroblast activation and improved hydration without overwhelming the fragile tissue. This makes them particularly suitable for patients who require subtle yet effective rejuvenation.
Successful application of polynucleotides under eyes treatment requires a precise understanding of periocular anatomy. The skin in this region is only 0.3–0.5 mm thick—among the thinnest in the body—while beneath lie important vascular and lymphatic structures such as the infraorbital vessels. This unique anatomy explains both the sensitivity of the area and its vulnerability to complications if injections are performed incorrectly. Proper technique not only ensures optimal results but also minimizes the risk of complications such as edema, bruising, or vascular injury.
Fine-gauge needles (commonly 30G) or blunt cannulas are preferred to reduce tissue trauma.
Injections are typically administered into the superficial subdermal or dermal layer, avoiding deeper structures like the orbital septum.
Fine-gauge needles can be used for precision, but blunt-tip cannulas often provide safer navigation through fragile tissue, reducing the risk of bruising or vascular injury.
Microbolus or linear threading techniques are recommended for even distribution and smooth correction.
Gentle massage following injection helps to prevent nodules and ensures homogeneous product integration.
Small, evenly distributed amounts are preferable to avoid nodules or edema, particularly in patients with thin or translucent skin.
Avoid areas with active infection, inflammation, or compromised skin.
Always aspirate if using techniques near larger vessels to reduce the risk of intravascular injection.
By adhering to these principles, practitioners can maximize the regenerative benefits of PN while ensuring patient safety.
When performed by trained professionals with appropriate products, under eye polynucleotide treatment is considered a safe and effective procedure. Polynucleotides are biocompatible and promote tissue repair rather than simply filling space, which makes them well-suited for delicate periocular skin. However, as with all injectable treatments, there are potential risks that must be carefully managed.
Common mild effects:
Temporary redness, swelling, or slight bruising at the injection site
Mild tenderness that typically resolves within 1–2 days
Less frequent but important risks:
Persistent edema, particularly in patients prone to fluid retention
Vascular injury or hematoma if injection technique is imprecise
Tyndall effect or visible irregularities when injected too superficially
The likelihood of adverse effects decreases significantly with correct technique, careful patient selection, and the use of high-quality formulations. Products such as PNPURE™ NeoEye pn filler, with its purified polynucleotide complex and added hydrating components, are designed to minimize irritation while ensuring targeted under-eye rejuvenation.
Despite its safety profile, certain conditions require caution or avoidance:
Active skin infections or inflammatory conditions around the eyes.
Known hypersensitivity to polynucleotide products or any formulation components.
Patients with bleeding disorders or those on anticoagulant therapy.
Recent eyelid or ocular surgery until full recovery.
Pregnancy or breastfeeding, due to limited safety data.
By carefully evaluating these factors, practitioners can optimize outcomes while minimizing risk, making polynucleotide treatment under eyes a highly suitable option for targeted, delicate rejuvenation.
Patients often wonder what to expect before and after polynucleotide treatment under eyes, both in terms of visible improvements and the recovery process. Understanding these timelines helps set realistic expectations and ensures patient satisfaction.
Immediate Effects:
Within 2–4 days of the first session, skin texture begins to feel smoother.
Early hydration improves the overall brightness and suppleness of the under-eye area.
Short-Term Improvements:
After 2–3 weeks, elasticity and firmness increase noticeably.
Fine lines begin to soften, and mild dark circles may appear less prominent.
Long-Term Results:
Following multiple sessions (typically 3–4, spaced appropriately), the dermal structure is strengthened.
Patients often observe improved skin tightness, reduced discoloration, and a naturally rejuvenated appearance.
Histological studies show sustained fibroblast activity, enhanced collagen synthesis, and improved microvascular function, ensuring longer-lasting effects compared with conventional non-crosslinked hyaluronic acid treatments.
Recovery Considerations:
Minimal downtime: mild swelling, redness, or small bruises may occur but typically resolve within a few days.
Patients are advised to avoid intense physical activity, alcohol, or exposure to extreme temperatures for 24–48 hours post-treatment.
The gentle nature of polynucleotide formulations like PNPURE™ NeoEye makes recovery smoother and lowers the incidence of complications such as nodules or vascular injury.
Polynucleotide treatment under eyes – Quick Reference for Clinicians
Before performing polynucleotide treatment under eye, confirm the following:
☐ Patient presents with mild to moderate under-eye concerns: dark circles, fine lines, loss of elasticity, or dullness.
☐ No active infections, inflammation, or dermatitis in the periorbital area.
☐ No known hypersensitivity to polynucleotides or formulation components.
☐ Patient is not on anticoagulants or has bleeding disorders.
☐ No recent eyelid or ocular surgery; patient is fully recovered.
☐ Not pregnant or breastfeeding.
Needle: 30G or blunt cannula; Depth: superficial subdermal.
Technique: microbolus or linear threading; use conservative volumes.
Post-care: gentle massage, monitor for mild swelling or bruising.
2–4 days post-treatment: Assess early hydration, swelling, and patient tolerance.
2–3 weeks: Evaluate elasticity improvements and fine line reduction; plan second session if needed.
3–5 weeks: Confirm dermal structural improvements and overall skin quality; adjust volume for subsequent sessions.
Ongoing Maintenance: Depending on patient response and aesthetic goals, additional sessions can be scheduled every 4–6 months to maintain results.
This structured, practical approach allows clinicians to maximize the efficacy and safety of pn treatment under eye, providing predictable outcomes while minimizing complications.
For clinics and aesthetic professionals interested in offering this advanced treatment—or for patients looking to experience its benefits—contact us today to receive a personalized quote and learn about current promotions.
