For aesthetic practitioners and patients alike, questions about product safety and reversibility are vital when choosing a dermal filler. One of the most frequently asked questions in clinics today is: does hyaluronidase work with CaHA filler? Understanding this is critical for managing treatment plans, handling complications, and setting realistic expectations for filler longevity. In this article, we provide a detailed, science-based explanation to help you make informed decisions.
Calcium hydroxylapatite (CaHA) is a biocompatible, biodegradable filler material composed of calcium and phosphate ions—elements naturally found in human bones. In aesthetic medicine, CaHA are designed as microspheres suspended in a gel carrier. Unlike hyaluronic acid (HA) fillers, CaHA stimulates long-term collagen production while delivering immediate volume correction.
After injection of CHArmacy® caha filler, the gel component provides instant volume, while the CaHA microspheres act as a scaffold to stimulate fibroblast activity, leading to gradual collagen production. Over time, the gel is absorbed, and the CaHA particles are metabolized naturally without leaving residues. This dual-phase mechanism is a major reason behind the filler’s longevity, often lasting up to 18-24 months or more.
Hyaluronidase is an enzyme specifically designed to hydrolyze hyaluronic acid. It breaks down HA molecules, allowing for rapid dispersion and reabsorption. In clinical aesthetics, it's primarily used to correct overfilling, dissolve misplaced HA fillers, or address complications like vascular occlusion.
While hyaluronidase is highly effective for HA fillers, it does not interact with non-HA materials such as poly-L-lactic acid (PLLA), polymethyl methacrylate (PMMA), or CaHA. Therefore, hyaluronidase does not work on CaHA fillers in terms of dissolving or reversing their effects.
In some CaHA formulations, the carrier gel may contain minimal HA or CMC (carboxymethyl cellulose). While hyaluronidase might slightly affect HA in the gel, it has no impact on the solid CaHA microspheres that are responsible for the filler’s volumizing and collagen-inducing properties.
In cases where an immediate reversal of CaHA is desired—for example, due to poor injection placement or a rare complication—hyaluronidase cannot serve as a reliable solution. Instead, alternative methods like aspiration, saline massage, or surgical removal may be considered depending on severity.
Many assume that hyaluronidase can "dissolve any filler." This is incorrect. It only targets HA-based fillers and has no enzymatic action on CaHA. Misunderstanding this can delay appropriate treatment.
While HA fillers are popular partly due to their reversibility, CaHA fillers are chosen for their durability and collagen-stimulating effects. Understanding the trade-offs is crucial for patient satisfaction.
CHArmacy® from Dermax is engineered using Ventrix Tech™, a proprietary CaHA technology designed to maximize filler stability and patient safety. The formulation includes solid CaHA microspheres with a controlled particle size of 25-45 μm and a narrow size distribution range of less than 0.7. This uniformity minimizes post-injection complications such as swelling or immune responses.
The hybrid matrix of CMC and HA in CHArmacy® allows for immediate volumization. Over time, the HA is absorbed while the CaHA stimulates new collagen generation around the microspheres. Patients benefit from both short-term aesthetic enhancement and long-term skin regeneration, with effects lasting up to two years or more.
CHArmacy® features:
Elastic modulus of approximately 900 Pa for excellent support and shaping
Rough-surfaced microspheres to enhance fibroblast adhesion
Ultra-low porosity to ensure stability in soft tissue
These elements contribute to its superior safety profile and injection predictability.
CHArmacy® is suitable for:
Forehead
Glabellar lines
Nasal contouring
Temples
Mid-cheek volume loss
Nasolabial folds
Marionette lines
Jawline
Chin enhancement
Proper Injection Techniques
To mitigate risks, CaHA fillers should only be administered by trained professionals familiar with the product’s rheology and facial anatomy.
Post-Treatment Monitoring
Any signs of adverse effects should be evaluated promptly. As hyaluronidase cannot reverse CaHA, early detection and physical intervention are key.
Choose Reputable Suppliers
Opt for clinically tested, GMP-certified products like CHArmacy® that combine safety, performance, and cost-effectiveness. At Dermax, we support bulk purchases with competitive pricing and global logistics support.
So, does hyaluronidase work with CaHA filler? The clear answer is no—at least, not in the way it does with HA-based fillers. While hyaluronidase is invaluable for managing HA filler complications, CaHA requires a different clinical approach. When used correctly, CaHA fillers like CHArmacy® offer long-lasting, collagen-enhancing results with minimal risk.
For aesthetic providers looking for durability, precision, and safety, CHArmacy® stands as a trusted, affordable choice in the next generation of facial fillers.
