Types of Dermal Fillers: HA, CaHA, PLLA & PMMA Explained

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In the world of aesthetic treatments, dermal fillers are among the most popular non-surgical solutions for facial rejuvenation. These injectable treatments help restore volume, smooth out wrinkles, and enhance facial features. With a variety of fillers available, it can be overwhelming to choose the right one. In this blog, we'll take a closer look at the most common types of dermal fillers—Hyaluronic Acid (HA), Calcium Hydroxyapatite (CaHA), Poly-L-Lactic Acid (PLLA), and Polymethyl Methacrylate (PMMA)—and explore the various brands associated with each, helping you understand which option may be best for your needs.


1. Hyaluronic Acid Filler


Many of the best-known dermal fillers are made of hyaluronic acid, as it's an incredibly versatile product with a high safety profile. It's also a substance that's naturally produced by the body and can hold up to 1000 times its weight in water, for instant volumizing and hydrating effects. HA fillers are typically soft and gel-like. The results are temporary, lasting 6 to 12 months or longer before the body gradually and naturally absorbs the particles. Most HA fillers are infused with lidocaine to help minimize discomfort during and after treatment.


Brand names include: Aqua Secret® , Macrolite®

Hyaluronic Acid Filler aqua secret

Best For:


· Facial volume restoration (cheeks, temples)

· Lip enhancement

· Smoothening wrinkles and fine lines (nasolabial folds, crow's feet)

· Under-eye hollows

· Breast and buttock enlargement


Duration:


Hyaluronic acid face fillers typically last 6 to 12 months, while body fillers for breast and buttock augmentation last 12 to 18 months, depending on factors like the treatment area, lifestyle, and skin type. Regular maintenance sessions can help sustain optimal results over time. Get a quotation of AQUA SECRET hyaluronic acid filler price!



2. Calcium Hydroxyapatite Filler


Calcium Hydroxyapatite (CaHA) is a naturally occurring substance primarily found in our bones. In filler form, the CaHA particles are microscopically small and suspended in a smooth gel. CaHA fillers are generally thicker than hyaluronic acid fillers, offering not only immediate volume restoration but also stimulating collagen production for long-lasting results. These fillers typically last about 12 months for most patients.


Brand names include: CHArmacy®


CHArmacy® combines CaHA with Hyaluronic Acid (HA) for the best of both worlds. The CaHA microspheres provide immediate volume and structure to the skin, while the HA component hydrates and smooths the skin. Over time, the CaHA promotes collagen synthesis, improving skin elasticity and overall texture.


Calcium Hydroxyapatite Filler CHArmacy

Best For:

· Deep wrinkle treatment (nasolabial folds, marionette lines)

· Facial volumization (cheeks, chin)

· Collagen stimulation for long-term skin rejuvenation


Duration:

Results typically last 12 to 18 months, with collagen stimulation continuing to enhance skin quality even after the filler has broken down.

Get a quotation of CHArmacy caha filler price!



3. Poly-L-Lactic Acid Filler


Poly-L-Lactic Acid (PLLA) is a biodegradable, synthetic substance,it's known as a stimulator, that stimulates the body's natural collagen production. Unlike other fillers that add volume directly, PLLA fillers work gradually by encouraging the skin to produce more collagen over time, leading to a more youthful appearance. Results appear gradually and take four-to-six weeks to peak. Poly-L-lactic acid is typically used to treat deeper facial wrinkles, and results can last more than 2 years. now Devolux has new technology products can last 3 years,and also use for body sculpt.


Brand names include: Devolux®


The Devolux® series products are advanced biostimulators, primarily formulated with poly-L-lactic acid (PLLA). Among them, Devolux® Vital is a liquid formulation that combines PLLA with hyaluronic acid, specifically designed for facial volumization. The hyaluronic acid delivers immediate wrinkle-filling effects, while the PLLA stimulates collagen production, ensuring long-lasting results for up to two years. Devolux® Plus, on the other hand, is a lyophilized powder that blends PLLA with hyaluronic acid, featuring a particle size of 60-100μm. It is designed for breast and buttock augmentation and can last up to 2 years.


Poly-L-Lactic Acid Filler devolux


Best For:

· Overall facial volumization (cheeks, temples, chin)

· Deep wrinkles and sagging skin

· Long-term collagen stimulation for a natural youthful appearance


Duration:

The results of Devolux® are long-lasting, typically 2 to 3 years, as the body continues to produce collagen even after the filler has been absorbed.

Get a quotation of Devolux plla filler price!



4. Polymethyl Methacrylate Filler


Polymethylmethacrylate (PMMA) is a synthetic, biocompatible material that has been widely used in medicine for much of the past century. PMMA filler serves as a semi-permanent filler, composed of polymethylmethacrylate microspheres suspended in a smooth collagen gel base. Unlike hyaluronic acid fillers, PMMA microspheres act as a "scaffold" within the skin, encouraging the body to produce its own collagen over time. This newly formed collagen creates a foundation that restores volume and reduces the appearance of wrinkles. This injectable is particularly effective for treating medium to deep wrinkles and folds, with results that can last for up to five years.


Brand names include: PrimeFill®


PrimeFill® is an advanced dermal filler comprising 20% non-absorbable polymethylmethacrylate (PMMA) microspheres, each with a uniform diameter of 30 to 50 microns, suspended in 80% cross-linked sodium hyaluronate. This unique formulation stimulates the skin's natural collagen production, delivering long-lasting results. PrimeFill® is designed to provide benefits that last over 5 years. It is particularly effective for treating smile lines and acne scars but can be used on various areas of the face, excluding the lips.


Polymethyl Methacrylate Filler PrimeFill

Best For:


· Permanent wrinkle reduction (nasolabial folds, chin lines)

· Facial volumization (cheeks, jawline)

· Long-term results without the need for frequent touch-ups


Duration:

PrimeFill® offers permanent results, making it ideal for patients who want lasting volume restoration without the need for ongoing treatments.

Get a quotation of PremiFill pmma filler price!



Comparison Table: Types of Dermal Fillers


Filler Type

Ingredient

Applications

Longevity

Key Benefits

Hyaluronic Acid (HA)

Cross-linked Hyaluronic Acid

Lip enhancement, wrinkle reduction

6-12 months (face)

12-18 months (body)

Hydration, instant volume, and smooth texture.

Calcium Hydroxyapatite

Calcium Hydroxyapatite (CaHA)

Jawline, cheek contouring, deep wrinkles

~12 months

Stimulates collagen, natural-looking structure.

Poly-L-Lactic Acid

Poly-L-Lactic Acid (PLLA)

Volume loss, deep wrinkles

18-24 months

Gradual, natural collagen regeneration.

PMMA

Polymethylmethacrylate (PMMA)

Facial contouring, marionette lines

Over 5 years

Semi-permanent, cost-effective durability.


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Which Dermal Filler is Right for You?


Choosing the right dermal filler depends on your aesthetic goals, the areas you wish to treat, and how long you want the results to last. Here's a quick guide to help you decide:


· Aqua Secret® (HA filler) is perfect for patients looking for quick, effective results with minimal downtime. Ideal for fine lines, lip enhancement, and moderate volume loss.

· CHArmacy® (CaHA filler) is ideal for those seeking deeper wrinkle treatment and overall facial volumization, with the added benefit of collagen stimulation for long-term skin health.

· Devolux® (PLLA filler) is great for patients who prefer gradual, natural-looking results and long-lasting collagen stimulation. Best for overall volumization and sagging skin.

· PrimeFill® (PMMA filler) is the best option for patients seeking permanent results for deeper wrinkles and more significant facial volume restoration.


Consult with an experienced aesthetic professional to determine which filler best suits your needs and aesthetic goals.


Conclusion


For professional-grade products, choosing trusted brands ensures safety, efficacy, and satisfaction.

Dermal fillers offer a range of solutions tailored to different needs, and with these trusted brands, achieving aesthetic goals has never been more effective or accessible. Consult a qualified professional to determine the ideal filler for you!


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